Vendetta is loud, and due to change (4)
I believe the answer is:
feud
'vendetta' is the definition.
(I've seen this before)
'loud and due to change' is the wordplay.
'loud' becomes 'f' (short for forte - 'loud' in music).
'and' says to put letters next to each other.
'to change' indicates an anagram.
'due' is an anagram of 'eud'.
'f'+'eud'='FEUD'
'is' acts as a link.
(Other definitions for feud that I've seen before include "Squabble" , "Long-running quarrel" , "Conflict" , "Sustained enmity" , "Prolonged dispute" .)