Very busy certainly with head-to-toe treatments (9)

'very busy certainly' is the definition.
I can't judge whether this defines the answer.

'with head-to-toe treatments' is the wordplay.
'with' is a charade indicator (letters next to each other).
'head-to-toe' becomes 'mani' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'treatments' becomes 'cures' (cure is a kind of treatment).
'mani' next to 'cures' is 'MANICURES'.

Can you help me to learn more?