Very large inset I blame for resetting (11)
I believe the answer is:
inestimable
'very large' is the definition.
'inset i blame for resetting' is the wordplay.
'for resetting' is an anagram indicator.
'inset'+'i'+'blame'='insetiblame'
'insetiblame' is an anagram of 'INESTIMABLE'.
(Other definitions for inestimable that I've seen before include "Not able to be measured" , "Priceless" , "worth a fortune" , "Very great" .)