Very much depressed, man's time in game (4,5)
I believe the answer is:
solo whist
'game' is the definition.
(I've seen this before)
'very much depressed man's time' is the wordplay.
I cannot really understand how this works, but
'very' could be 'so' (both can mean 'extremely') and 'so' is located in the answer.
'depressed' could be 'low' (similar in meaning) and 'low' is found in the answer.
'man's' could be 'his' (belonging to a man) and 'his' is found in the answer.
'time' could be 't' (abbreviation) and 't' is present in the answer.
No letters remain.
This may be the basis of the clue (or it may be nonsense).
'in' acts as a link.
(Another definition for solo whist that I've seen is " game".)