Very sad; it may turn into misfortune (9)
I believe the answer is:
adversity
'misfortune' is the definition.
(adversity is a kind of misfortune)
'very sad it may turn' is the wordplay.
'very sad it' anagrams to 'ADVERSITY'.
But, I'm not sure how the anagram is indicated.
'into' is the link.
Can you help me to learn more?
(Other definitions for adversity that I've seen before include "Hard times or misfortune" , "Circumstances that cause trouble or sorrow" , "Misfortune, hardship" , "State of misfortune or affliction" .)