Very shrewd, by the way, and knows how to survive in the city (10)
I believe the answer is:
streetwise
'knows how to survive in the city' is the definition.
I know nothing about this answer so I can't tell whether it can be defined by this definition.
'very shrewd by the way' is the wordplay.
'very shrewd' becomes 'street' (I can't explain this - if you can you should believe this answer much more).
'by' says to put letters next to each other.
'the way' becomes 'wise' (wise is a kind of way).
'street'+'wise'='STREETWISE'
'and' acts as a link.
Can you help me to learn more?
(Other definitions for streetwise that I've seen before include "Canny" , "cynical, perhaps" , "Well adapted to urban life" , "Wily" , "Experienced in urban life" .)