Very sick at a holiday home (5)
I believe the answer is:
villa
'holiday home' is the definition.
(villa can mean a rented holiday home)
'very sick at a' is the wordplay.
'very' becomes 'v' (common abbreviation).
'sick' becomes 'ill' (similar in meaning).
'at' says to put letters next to each other.
'v'+'ill'+'a'='VILLA'
(Other definitions for villa that I've seen before include "See 3" , "where 6 [VERDI] lived?" , "Roman domicile" , "Large country house" , "Classical country house" .)