Vexation, distress (7)
I believe the answer is:
chagrin
This clue is a double definition.
'vexation' is the first definition.
(I've seen this in another clue)
'distress' is the second definition.
(thesaurus)
(Other definitions for chagrin that I've seen before include "irritation?" , "Embarrassment - rich nag (anag)" , "Annoyance/shame at one's failure" , "Arching with annoyance and embarrassment" , "Disappointment, exasperation" .)