Virginia in a temper to cause devastation (6)
I believe the answer is:
ravage
'devastation' is the definition.
(I've seen this before)
'virginia in a temper' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'in' is an insertion indicator.
'a temper' becomes 'rage' (I have seen 'Terrible temper' mean 'rage' so perhaps 'temper' could also mean 'rage').
'va' placed into 'rage' is 'RAVAGE'.
'to cause' is the link.
(Other definitions for ravage that I've seen before include "Greatly damage, destroy" , "Pillage or lay waste" , "Lay waste, plunder" , "Devastate, damage extensively" , "Act like a 6" .)