Virtue has come after loss of business, I say! (8,2)
I believe the answer is:
goodness me
'i say' is the definition.
I don't know anything about this answer so I cannot tell whether this works.
'virtue has come after loss of business' is the wordplay.
'virtue' becomes 'goodness' (I've seen this in another clue).
'has' means one lot of letters go next to another.
'after loss of' indicates named letters should be taken away.
'business' becomes 'co' (short for company).
'come' with 'co' removed is 'me'.
'goodness'+'me'='GOODNESS ME'
Can you help me to learn more?
(Another definition for goodness me that I've seen is " Well, well!".)