Vital force opposing Italian region (7)
I believe the answer is:
chianti
'italian region' is the definition.
(Chianti is a wine-producing region of Italy)
'vital force opposing' is the wordplay.
'vital force' becomes 'chi' (life force in Chinese philosophy).
'opposing' becomes 'anti' (prefix meaning 'opposing').
'chi'+'anti'='CHIANTI'
(Other definitions for chianti that I've seen before include "Chain it to popular Italian wine" , "Popular dry red wine of Tuscany" , "Italian wine - mountain range" , "I can hit for popular Italian wine" , "Wine produced in Tuscany" .)