Wakes up lopsided (5)
I believe the answer is:
askew
'lopsided' is the definition.
(synonyms)
'wakes up' is the wordplay.
'up' indicates an anagram (letters get chucked up).
'wakes' anagrammed gives 'ASKEW'.
(Other definitions for askew that I've seen before include "Towards one side, awry" , "in an odd position" , "Obliquely" , "Not true" , "Lopsided" .)