Walkers shriek when disturbed (6)
I believe the answer is:
hikers
'walkers' is the definition.
(hiker is a kind of walker)
'shriek when disturbed' is the wordplay.
'when disturbed' indicates an anagram.
'shriek' is an anagram of 'HIKERS'.
(Other definitions for hikers that I've seen before include "They walk the hills" , "people on road" , "They raise" , "People on foot" , "Ramblers" .)