Wanderer takes no notice after mile (5)
I believe the answer is:
nomad
'wanderer' is the definition.
(nomad is a kind of wanderer)
'no notice after mile' is the wordplay.
'notice' becomes 'ad' (both can mean an advertisement).
'after' is a charade indicator (letters next to each other).
'mile' becomes 'm' (common abbreviation).
'ad' put after 'm' is 'mad'.
'no'+'mad'='NOMAD'
'takes' is the link.
(Other definitions for nomad that I've seen before include "Rover" , "one of those with no fixed home" , "is one unsettled?" , "Unsettled character" , "Roving person" .)