Wanton and loose? Nuts ache! (8)
I believe the answer is:
unchaste
'wanton' is the definition.
('unchaste' can be similar in meaning to 'wanton')
'loose? nuts ache' is the wordplay.
'loose?' is an anagram indicator (letters are loosened from their original positions).
'nuts'+'ache'='nutsache'
'nutsache' anagrammed gives 'UNCHASTE'.
'and' acts as a link.
(Other definitions for unchaste that I've seen before include "Sexually immodest" , "Dissolute" , "Immoral, wanton" , "Engaging in illicit affairs" , "Lascivious" .)