Way to transport goods around island without success (2,4)
I believe the answer is:
in vain
'without success' is the definition.
(I've seen this before)
'way to transport goods around island' is the wordplay.
'way to transport goods' becomes 'in van' (goods may be transported in a van).
'around' means one lot of letters goes inside another.
'island' becomes 'i' (geographical abbreviation).
'invan' placed around 'i' is 'IN VAIN'.
(Other definitions for in vain that I've seen before include "useless" , "Without effect" , "'To no avail (2,4)'" , "Uselessly, without result" , "Uselessly, without success" .)