Weak argument about one. Literally (10)
I believe the answer is:
debilitate
'weak argument about one literally' is the definition.
I can't judge whether this defines the answer.
'weak argument about one literally' is the wordplay.
'weak argument' becomes 'debate' (synonyms. I am not sure about the 'weak' bit.).
'about' indicates putting letters inside.
'one' becomes 'i' (Roman numeral).
'literally' becomes 'lit' (abbreviation, eg in translations).
'i'+'lit'='ilit'
'debate' enclosing 'ilit' is 'DEBILITATE'.
Can you help me to learn more?
(Other definitions for debilitate that I've seen before include "Weaken" , "Make very weak" .)