Weaken juice (3)
I believe the answer is:
sap
I believe this clue is a double definition.
'weaken' is the first definition.
(thesaurus)
'juice' is the second definition.
(thesaurus)
(Other definitions for sap that I've seen before include "It's plant juice, idiot" , "Undermine; fool" , "Enervate" , "Fluid in plant stem" , "Watery substance in plants" .)