Wean off afresh (4)
I believe the answer is:
anew
'afresh' is the definition.
(I've seen this before)
'wean off' is the wordplay.
'off' is an anagram indicator.
'wean' anagrammed gives 'ANEW'.
(Other definitions for anew that I've seen before include "Again but differently" , "From the beginning again" , "Wane in a different way, again" , "Once more (poetic)" , "Afresh" .)