Weapon designed for pilots? (6)
I believe the answer is:
pistol
'weapon' is the definition.
(pistol is a kind of weapon)
'designed for pilots?' is the wordplay.
'designed for' is an anagram indicator (letters re-designed).
'pilots' is an anagram of 'PISTOL'.
(Other definitions for pistol that I've seen before include "Hand-held firearm" , "Officer's side-arm" , "making an appearance in Shakespeare's King Henry V" , "Shakespearean character" , "Piece" .)