Weary when ad interrupts invective (6)
I believe the answer is:
tirade
'invective' is the definition.
(thesaurus)
'weary when ad interrupts' is the wordplay.
'weary when' becomes 'tire' (synonyms. I am not sure about the 'when' bit.).
'interrupts' is an insertion indicator.
'tire' placed around 'ad' is 'TIRADE'.
Can you help me to learn more?
(Other definitions for tirade that I've seen before include "Long angry harangue" , "A prolonged outburst of angry words" , "Long speech of angry criticism" , "Inclination; fish" , "Stream of invective" .)