Crossword Genius

Wee man, no chum, playful Enterprise helmsman sent up (10)

Ross

I believe the answer is:

homunculus

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'wee man' is the definition.
The definition suggests a singular noun which matches the answer.

'no chum playful enterprise helmsman sent up' is the wordplay.
'playful' indicates anagramming the letters.
'enterprise helmsman' becomes 'sulu' (I've seen this in another clue).
'sent up' says the letters should be written backwards.
'sulu' backwards is 'ulus'.
'no'+'chum'='nochum'
'nochum' is an anagram of 'homunc'.
'homunc'+'ulus'='HOMUNCULUS'

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I've seen this clue in The Telegraph.
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