Wee Sam left Suriname (5)
I believe the answer is:
urine
'wee' is the definition.
(I've seen this before)
'sam left suriname' is the wordplay.
'left' is a deletion indicator.
'suriname' with 'sam' removed is 'URINE'.
(Other definitions for urine that I've seen before include "Stuff that's passed" , "Water that one passes" , "Waste product" , "Wee" .)