Weighty letter to Lois, perhaps (5)
I believe the answer is:
kilos
'weighty letter to lois perhaps' is the definition.
I can't judge whether this definition defines the answer.
'letter to lois perhaps' is the wordplay.
'letter' becomes 'k' ().
'perhaps' indicates an anagram.
'lois' is an anagram of 'ilos'.
'k'+'ilos'='KILOS'
Can you help me to learn more?
(Other definitions for kilos that I've seen before include "Metric weights" , "Units of mass" , "Units of weight in metric system" , "Units of weight of 1000 grams" .)