What a shame about the end of wholesome devotion (5)
I believe the answer is:
piety
'devotion' is the definition.
(I've seen this before)
'what a shame about the end of wholesome' is the wordplay.
'what a shame' becomes 'pity' (synonyms).
'about' is an insertion indicator.
'the end of' suggests the final letters.
The final letter of 'wholesome' is 'e'.
'pity' going around 'e' is 'PIETY'.
(Other definitions for piety that I've seen before include "Dutiful devotion" , "Holiness" , "Attentive religious practice" , "Being faithful" , "Religious feeling" .)