What hands can give produce up (4)
I believe the answer is:
time
'what hands can give' is the definition.
(as in the hands on a clock)
'produce up' is the wordplay.
'produce' becomes 'emit'.
'up' is a reversal indicator (in down clue: letters go upwards).
'emit' backwards is 'TIME'.
(Other definitions for time that I've seen before include "Indefinite period" , "Measure of duration" , "Spell" , "Age" , "'. . . and tide wait for no man'" .)