What Sandra will do to make Sara abandon hope? (4,5)
I believe the answer is:
lose heart
'abandon hope?' is the definition.
(thesaurus)
'what sandra will do to make sara' is the wordplay.
I cannot quite understand how this works, but
'what' could be 'eh' (I've seen this in other clues) and 'eh' is found in the answer.
This may be the basis of clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for lose heart that I've seen before include "Become despondent" , "Become discouraged in cardiac manner?" , "What patient may do before subsequent transplant" , "Let hopes dwindle - real ethos involved" , "Become dispirited" .)