Crossword Genius

What's surprisingly anodyne makes one cross (7)

Ross

I believe the answer is:

annoyed

'one cross' is the definition.
(thesaurus)

'what's surprisingly anodyne' is the wordplay.
'what's surprisingly' indicates an anagram.
'anodyne' anagrammed gives 'ANNOYED'.

'makes' acts as a link.

(Other definitions for annoyed that I've seen before include "Anodyne (anag.)" , "'Irritated, impatient (7)'" , "Upset" , "Vexed, irritated" , "'Harassed, pestered (7)'" .)

I've seen this clue in The Telegraph.
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