When everything seems to fail, yet nosh with seafood works (3,2,5,4)
I believe the answer is:
one of those days
'when everything seems to fail' is the definition.
I don't know anything about this answer so I cannot judge whether this works.
'yet nosh with seafood works' is the wordplay.
'with' means one lot of letters go next to another.
'works' indicates an anagram (work can mean to twist or convulse).
'yet'+'nosh'+'seafood'='yetnoshseafood'
'yetnoshseafood' anagrammed gives 'ONE OF THOSE DAYS'.
Can you help me to learn more?
(Another definition for one of those days that I've seen is " such a difficult time".)