Where a cobbler may be, missing Times unfortunately (4)
I believe the answer is:
alas
'unfortunately' is the definition.
('alas' is used to express regret)
'where a cobbler may be missing times' is the wordplay.
I cannot quite see how this works, but
'a' is present in the answer.
The remaining letters 'las' is a valid word which might be clued in a way I don't understand.
This explanation may well be incorrect...
(Other definitions for alas that I've seen before include "Lackaday" , "Sad expression" , "Exclamation of grief" , "What a shame!" , "Sadly, unfortunately" .)