Where men go home through river (6)
I believe the answer is:
urinal
'where men go' is the definition.
(as in going to the toilet)
'home through river' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'through' indicates putting letters inside (I've seen this in other clues).
'river' becomes 'ural' (I've seen this in other clues).
'in' going within 'ural' is 'URINAL'.
(Other definitions for urinal that I've seen before include "Sanitary fitting" , "waste disposal unit" , "public convenience" .)