Wicked holiday home across the Atlantic with nothing in (10)
I believe the answer is:
villainous
'wicked' is the definition.
(similar in meaning)
'holiday home across the atlantic with nothing in' is the wordplay.
'holiday home' becomes 'villa' (villa can mean a rented holiday home).
'across the atlantic' becomes 'in US' (in the United States).
'with' means one lot of letters go next to another.
'nothing' becomes 'O' (looks like zero - 0).
'in' is an insertion indicator.
'villa'+'inus'='villainus'
'villainus' placed around 'o' is 'VILLAINOUS'.
(Other definitions for villainous that I've seen before include "criminal" , "dramatically bad" , "really bad" , "Nasty" , "very unpleasant" .)