Wicked Iago's opening lines (3)
I believe the answer is:
ill
'wicked' is the definition.
(I've seen this before)
'iago's opening lines' is the wordplay.
'opening' says to take the initial letters.
'lines' becomes 'll' (an abbreviation for line written twice).
The initial letter of 'iago' is 'i'.
'i'+'ll'='ILL'
(Other definitions for ill that I've seen before include "Misfortune" , "'Never speak . . . of the dead'" , "Groggy" , "In short, the state of Chicago" , "Poorly" .)