Wicked leader in Orient with big house in America (10)
I believe the answer is:
villainous
'wicked' is the definition.
(similar in meaning)
'leader in orient with big house in america' is the wordplay.
'leader in' says to take the initial letters.
'with' says to put letters next to each other.
'big house' becomes 'villa' (villa is a kind of house. I am not sure about the 'big' bit.).
'america' becomes 'US' (United States).
The initial letter of 'orient' is 'o'.
'villa'+'in'='villain'
'o' after 'villain' is 'villaino'.
'villaino'+'us'='VILLAINOUS'
Can you help me to learn more?
(Other definitions for villainous that I've seen before include "criminal" , "Nasty" , "very unpleasant" , "dramatically bad" , "really bad" .)