Wife gets poorly beforehand and afterwards, leading to animosity (3,4)
I believe the answer is:
ill will
'animosity' is the definition.
(I've seen this before)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for ill will that I've seen before include "Bitterness" , "Bad feeling towards, hostility" , "Positively unfriendly disposition" , "Hostility, malevolence" , "causing resentment" .)