Wife leaves fool for friend (4)
I believe the answer is:
ally
'friend' is the definition.
(an ally is a friend or supporter)
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for ally that I've seen before include "couple?" , "Comrade in arms" , "Accomplice" , "One in cooperation with another" , "Co-operating person or nation" .)