Wife of William S., say, raised hell (7)
I believe the answer is:
gehenna
'hell' is the definition.
(I know that Gehenna is a type of hell)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for gehenna that I've seen before include "Judaism's Hell" , "pit" , "underworld" , "place of punishment" , "hellish situation" .)