Wife poorly following second drink (5)
I believe the answer is:
swill
'drink' is the definition.
(swilling is a kind of drinking)
'wife poorly following second' is the wordplay.
'wife' becomes 'w' (abbreviation).
'poorly' becomes 'ill' (synonyms).
'following' says to put letters next to each other.
'second' becomes 's' (common abbreviation).
'w'+'ill'='will'
'will' after 's' is 'SWILL'.
(Other definitions for swill that I've seen before include "Refuse" , "Pigfeed" , "Wet pig feed" , "Pig-food; rinse" , "Pigs' food" .)