Wife ruined this game (5)
I believe the answer is:
whist
'game' is the definition.
(whist is a card game)
'wife ruined this' is the wordplay.
'wife' becomes 'w' (abbreviation).
'ruined' is an anagram indicator.
'this' is an anagram of 'hist'.
'w'+'hist'='WHIST'
(Other definitions for whist that I've seen before include "Card game for four" , "Tricky card game" , "Popular card game, sometimes solo" , "Old card game" , "calls for silence?" .)