Wild animals' centre in Italy (5)
I believe the answer is:
'in italy' is the definition.
('Milan' is part of 'italy')
'wild animals' centre' is the wordplay.
'wild' indicates anagramming the letters.
'centre' indicates the central letters.
The central letters of 'animals' are 'nimal'.
'nimal' with letters rearranged gives 'MILAN'.
(Other definitions for milan that I've seen before include "province" , "City of northern Italy" , "European city" , "Italian city with La Scala opera house" , "Capital of Lombardy" .)