Will Shakespeare's first grand house (5)
I believe the answer is:
shall
'will shakespeare's' is the definition.
'shall' can be an answer for 'will' ('shall' can be a synonym of 'will'). I'm unsure of the 'shakespeare's' bit.
'first grand house' is the wordplay.
'first grand' becomes 's' (I am not sure about this - if you are sure you should believe this answer much more).
'house' becomes 'hall' (hall is a kind of house).
's'+'hall'='SHALL'
Can you help me to learn more?
(Other definitions for shall that I've seen before include "Will, must, is to" , "' - - We Dance?'" .)