Winding tramline comes to depot (8)
I believe the answer is:
terminal
'to depot' is the definition.
(synonyms)
'winding tramline' is the wordplay.
'winding' indicates an anagram.
'tramline' anagrammed gives 'TERMINAL'.
'comes' acts as a link.
(Other definitions for terminal that I've seen before include "Ending in death" , "Last, final" , "Tramline at the last stage of a fatal disease" , "Arrivals or departures building" , "At the end, final" .)