Wine makes mules act strangely (8)
I believe the answer is:
muscatel
'wine' is the definition.
(muscatel is a kind of wine)
'mules act strangely' is the wordplay.
'strangely' is an anagram indicator.
'mules'+'act'='mulesact'
'mulesact' with letters rearranged gives 'MUSCATEL'.
'makes' is the link.
(Other definitions for muscatel that I've seen before include "Type of wine - calumets (anag)" , "Rich sweet wine" , "Sweet grape variety" , "Sweet aromatic grape used for raisins, wine" , "drink" .)