Wine manuscript is Minister’s responsibility (9)
I believe the answer is:
portfolio
'minister's responsibility' is the definition.
(I've seen this before)
'wine manuscript' is the wordplay.
'wine' becomes 'port wine' (port wine is a kind of wine).
'manuscript' becomes 'folio' (I've seen this in another clue).
'port'+'folio'='PORTFOLIO'
'is' acts as a link.
(Other definitions for portfolio that I've seen before include "Cabinet responsibility" , "Set of collected pieces of creative work" , "Flat case for paper sheets" , "Minister's responsibility" , "governmental responsibility" .)