Wine spot creates problem for photo (3,3)
I believe the answer is:
red eye
'problem for photo' is the definition.
(problem affecting a photograph)
'wine spot' is the wordplay.
'wine' becomes 'red' (red is a type of wine).
'spot' becomes 'eye' (both can mean to notice or observe).
'red'+'eye'='RED-EYE'
'creates' is the link.
(Other definitions for red eye that I've seen before include "problem for paparazzi?" , "Effect of shooting" , "Poor quality US whisky" , "avoided by careful photographers" , "Poor spirit" .)