Wink from Bill associated with American First Ladies (6)
I believe the answer is:
signal
'wink' is the definition.
(thesaurus)
'bill associated with american first ladies' is the wordplay.
'bill' becomes 'sign' (I am not sure about this - if you are sure you should believe this answer much more).
'associated with' says to put letters next to each other.
'american' becomes 'a' (common abbreviation - e.g. in organisation names).
'first ladies' becomes 'l' (sst letter of 'ladies').
'sign'+'a'+'l'='SIGNAL'
'from' acts as a link.
Can you help me to learn more?
(Other definitions for signal that I've seen before include "intimation" , "Remarkable; gesture" , "Gesture giving information or command" , "Aligns (anag) -- gesture" , "Noteworthy" .)