Wise guy hurt, plonker initially poking nasty wound (11)
I believe the answer is:
smartypants
'wise guy' is the definition.
I know nothing about this answer so I can't judge whether it can be defined by this definition.
'hurt plonker initially poking nasty wound' is the wordplay.
'hurt' becomes 'smart' (synonyms).
'initially' says to take the initial letters.
'poking' means one lot of letters goes inside another (poke can mean to create a hole in).
'wound' is an anagram indicator (wound can mean twisted or turned around).
The initial letter of 'plonker' is 'p'.
'nasty' anagrammed gives 'yants'.
'p' inserted inside 'yants' is 'ypants'.
'smart'+'ypants'='SMARTYPANTS'
Can you help me to learn more?
(Another definition for smartypants that I've seen is " Know-all".)