Wise, like pharaoh heading for Egypt (6)
I believe the answer is:
astute
'wise' is the definition.
(thesaurus)
'like pharaoh heading for egypt' is the wordplay.
'like' becomes 'as'.
'pharaoh' becomes 'tut' (colloquial name for Tutankhamun).
'heading for' indicates taking the first letters.
The initial letter of 'egypt' is 'e'.
'as'+'tut'+'e'='ASTUTE'
(Other definitions for astute that I've seen before include "Sharp-witted" , "Subtle" , "Discerning" , "Able to assess (people or situations) accurately" , "on the ball" .)