With 124-Across, dreaded time of the year for many allergy sufferers (6)

I believe the answer is:

pollen

(Other definitions for pollen that I've seen before include "Fine powder discharged from a plant" , "Fertilising powder from plants" , "Powdery substance given off by flowers" , "Powdery substance given off by plants" , "Airborne 10 across" .)

I've seen this clue in the King Feature Syndicate.

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