With a clean slate (4)
I believe the answer is:
anew
'with a clean slate' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for anew that I've seen before include "Once more (poetic)" , "Again but differently" , "From the beginning again" , "Wane in a different way, again" , "Afresh" .)